Interaction of Peptide-Protein(AdiponinTM - Adiponectin Receptor Bond)
A peptide is a short chain of 2 to 50 amino acids, each of which serves as a building block of protein.
When three amino acids combine to form a peptide, it is called a “tripeptide.”
Tripeptides are small enough to diffuse through the skin efficiently,
so that they are highly beneficial drug and cosmetic active ingredients.
Techniques for conversion of useful human proteins to 3-mer functional peptides, which contain unique advantages over small molecule and protein agents
Identification of PPI Hotspots
Translation into Peptide
Even the best materials cannot function unless they are properly absorbed through the skin.
Tripeptides are small enough to be effectively absorbed through the skin. On the other hand, protein-based cosmetic products do not often produce optimal effects because they are too large to penetrate the skin. Although liposome or meso-roller helps to increase skin absorption, they have limitations. SupadElixir uses advanced technology to overcome these limitations.
53 Amino acid
6,200 Dalton MW
3 Amino acid
500 Dalton MW
SE-Tripeptide vs EGF
The 500 Dalton rule for the skin penetration
(SE-Tripeptide vs Other Peptides)
SE-Tripeptides penetrate into cells
Cells were treated with AMC-conjugated tripeptide(fluorescence) and observed under fluorescence microscopy.
SE-Tripeptides are stable at room temperature and preserves their structural integrity under harsh conditions such as 50℃ for 4 weeks. In addition, SE-tripeptides can be autoclaved without decomposition at 121℃ for 15 minutes, suggesting that their stability is high enough to be clinically applied after self-sterilization.
HPLC ( High Performance Liquid Chromatography) analysis
SE-Tripeptide up-regulates the expression of collagen and elastin in human fibroblast (CCD-986sk)
Human fibroblast cells were treated with FITC conjugated antibodies against COL1A and Elastin for detection by fluorescence microscopy .