Interaction of Peptide-Protein(AdiponinTM - Adiponectin Receptor Bond)
A peptide is a short chain of 2 to 50 amino acids, each of which serves as a building block of protein.
When three amino acids combine to form a peptide, it is called a “tripeptide.”
Tripeptides are small enough to diffuse through the skin efficiently,
so that they are highly beneficial drug and cosmetic active ingredients.
Techniques for conversion of useful human proteins to 3-mer functional peptides, which contain unique advantages over small molecule and protein agents
Identification of PPI Hotspots
Translation into Peptide
Even the best materials cannot function unless they are properly absorbed through the skin.
Tripeptides are small enough to be effectively absorbed through the skin. On the other hand, protein-based cosmetic products do not often produce optimal effects because they are too large to penetrate the skin. Although liposome or meso-roller helps to increase skin absorption, they have limitations. SupadElixir uses advanced technology to overcome these limitations.
53 Amino acid
6,200 Dalton MW
3 Amino acid
500 Dalton MW
Molecular Weight Comparison
with EGF Peptide
The 500 Dalton rule for the skin penetration
(SE-Tripeptide™ vs Other Peptides)
SE-Tripeptide™ penetrate into dermis layer
3D human skin model was treated with AMC-conjugated tripeptide(Blue) or FITC-conjugated EGF (Green)
and then observed under fluorescence microscopy.
SE-Tripeptide™ bind to target protein with a high specificity.
Melanocytes were treated with AMC-conjugated Mitefin™ (Blue) or Rhodamine-conjugated MITF (Red) and then observed under fluorescence microscopy.
Mitefin™ specifically binds to MITF in nucleus.
SE-Tripeptide™ is a biocompatible substance.
|Total aerobic microbial count||Not detected|
|1st skin irritation test||Non-irritant|
|Cumulative stimulation sensitization test||Non-irritant|
SE-Tripeptide™ are stable at room temperature and preserves their structural integrity under harsh conditions such as 50℃ for 4 weeks.
HPLC ( High Performance Liquid Chromatography) analysis
SE-Tripeptide™ has a superior efficacy.
Human fibroblast cells were treated with FITC conjugated antibodies against COL1A and Elastin for detection by fluorescence microscopy .