Platform Technology

Interaction of Peptide-Protein(AdiponinTM - Adiponectin Receptor Bond)

About Peptide

A peptide is a short chain of 2 to 50 amino acids, each of which serves as a building block of protein.

When three amino acids combine to form a peptide, it is called a “tripeptide.” Tripeptides are small enough to diffuse through the skin efficiently,

so that they are highly beneficial drug and cosmetic active ingredients.

Core Bio-Science of SupadElixir

Techniques for conversion of useful human proteins to 3-mer functional peptides, which contain unique advantages over small molecule and protein agents

Identification of PPI Hotspots

Translation into Peptide

Advantages of SE-Tripeptide

Even the best materials cannot function unless they are properly absorbed through the skin.

Tripeptides are small enough to be effectively absorbed through the skin. On the other hand, protein-based cosmetic products do not often produce optimal effects because they are too large to penetrate the skin. Although liposome or meso-roller helps to increase skin absorption, they have limitations. SupadElixir uses advanced technology to overcome these limitations.

EGF

53 Amino acid
6,200 Dalton MW

SE-Tripeptide

3 Amino acid
500 Dalton MW

SE-Tripeptide vs EGF

The 500 Dalton rule for the skin penetration
(SE-Tripeptide vs Other Peptides)

Cell penetration test

SE-Tripeptides penetrate into cells

Cells were treated with AMC-conjugated tripeptide(fluorescence) and observed under fluorescence microscopy.

Peptide stability test

SE-Tripeptides are stable at room temperature and preserves their structural integrity under harsh conditions such as 50℃ for 4 weeks. In addition, SE-tripeptides can be autoclaved without decomposition at 121℃ for 15 minutes, suggesting that their stability is high enough to be clinically applied after self-sterilization.

HPLC ( High Performance Liquid Chromatography) analysis

Efficacy (in vitro)test

SE-Tripeptide up-regulates the expression of collagen and elastin in human fibroblast (CCD-986sk)

Human fibroblast cells were treated with FITC conjugated antibodies against COL1A and Elastin for detection by fluorescence microscopy .

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